Novel gallium-mediated C3-allylation of indoles and pyrroles in aqueous media promoted by Bu4NBr |
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| Authors: | Dipak Prajapati Mukut Gohain Baikuntha J. Gogoi |
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| Affiliation: | Medicinal Chemistry Division, Regional Research Laboratory, Jorhat 785 006, Assam, India |
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| Abstract: | A mild and efficient protocol for the coupling of indoles and pyrroles with allyl halides such as allyl bromide, crotyl bromide and propargyl bromide in the presence of gallium metal in a Bu4NBr-DMF-H2O system has been developed. The reaction is equally effective when cadmium is used in lieu of gallium and the corresponding 3-allyl indoles and 3-allyl pyrroles were obtained in almost comparable yields. |
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| Keywords: | Gallium Cadmium Aqueous media |
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