The first bismuth(III)-catalyzed guanylation of thioureas |
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Authors: | Silvio Cunha Manoel T Rodrigues Jr |
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Institution: | Instituto de Qu?´mica, Universidade Federal da Bahia, Campus de Ondina, Salvador-BA 40170-290, Brazil |
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Abstract: | This work describes the first catalytic bismuth-promoted synthesis of polysubstituted guanidines in good yields through the guanylation reaction of N-benzoyl or N-phenylthioureas with primary and secondary amines, but now employing equimolar amounts of each organic reagent. Both bismuth iodine and bismuth nitrate were efficient as inorganic thiophiles at only 5 mol % in relation to substrates, being the first example of inorganic thiophiles acting in guanylation at catalytic levels. |
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Keywords: | Thioureas Guanidines Bismuth |
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