Solvent free preparation of amidophosphonates from isocyanides

New amidophosphonates are prepared via a two-step Mannich/Ugi one-pot procedure from isocyanides. Aminophosphonates are readily prepared from primary amines, dialkyl phosphites and carbonyl compounds under LiClO₄ catalysis without any solvent. After completion, addition of an isocyanide, an aldehyde and acetic acid give access to phosphono Ugi-type adducts in good to moderate yields.