Palladium mediated cycloisomerization of sugar alkynols: synthesis of cyclic enol-ethers and spiroketals |
| |
| Authors: | CV Ramana Rosy Mallik Rajesh G Gonnade Mukund K Gurjar |
| |
| Institution: | National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India |
| |
| Abstract: | Functionalized bicyclic enol-ethers and spiroketals are prepared by Pd catalyzed cycloisomerization of 3-C-alkynylfuranosyl derivatives. Cycloisomerization of differently substituted alkyne derivatives revealed a preference for 6-endo-dig cyclization over 5-exo-dig if the substituent is not sufficiently electron withdrawing. The scope of these cycloisomerizations has been further extended by integrating with conjugate addition. |
| |
| Keywords: | Palladium Cycloisomerization C-alkynylfuranose Spiroketal Enol-ether |
| 本文献已被 ScienceDirect 等数据库收录！ |
