A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3 |
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| Authors: | Oraphin Chantarasriwong Warinthorn Chavasiri |
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| Institution: | a Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand
b Department of Chemistry, Yonsei University, Wonju 220-710, Republic of Korea |
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| Abstract: | Cl3CCN in combination with PPh3 proved to be a highly reactive reagent for the conversion of sulfonic acids to the corresponding sulfonyl chlorides in refluxing CH2Cl2. Upon reaction with amines, the corresponding sulfonamides were obtained in good to excellent yields. |
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