A new solvent system for efficient synthesis of 1,2,3-triazoles |
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| Authors: | Bo-Young Lee Kwan Soo Kim |
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| Affiliation: | Center for Bioactive Molecular Hybrids, Department of Chemistry, Yonsei University, Seodaemun-gu Sinchon-dong 134, Seoul 120-749, Republic of Korea |
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| Abstract: | The use of CH2Cl2 as a co-solvent with H2O in the copper(I)-catalyzed 1,3-dipolar cycloaddition of organic azides and alkynes increased reaction rates and provided the corresponding 1,2,3-triazoles in excellent yields compared to other organic co-solvent systems. Moreover, we applied this discovery to prepare the functional multivalent compound in an excellent yield. |
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