A practical synthetic route to 4′-alkylaristeromycin derivatives: 4′-methylaristeromycin |
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| Authors: | Xue-qiang Yin |
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| Institution: | Department of Chemistry and Biochemistry, Auburn University, Auburn, AL 36849-5312, United States |
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| Abstract: | (−)-(1S,4R)-4-Hydroxy-2-cyclopenten-1-yl acetate provided a convenient entry point for a 16-step chiral preparation of 4′-methylaristeromycin. This procedure is adaptable to a number of carbocyclic nucleosides with a diversity of substitution at C-4′ and C-5′ and a variety of heterocyclic bases. |
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| Keywords: | Carbocyclic nucleosides Mitsunobu coupling Cyclopentanones |
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