Studies directed towards the synthesis of antascomicin A: stereoselective synthesis of the C22-C34 fragment of the molecule |
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| Authors: | Tushar Kanti Chakraborty Bajjuri Krishna Mohan Midde Sreekanth |
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| Institution: | Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | A stereoselective synthesis of the C22-C34 fragment of the non-immunosuppressive immunophilin-binding natural product, antascomicin A was achieved using d-quinic acid as the starting material and highly stereoselective aldol reactions were employed, as key steps, to build the remaining stereocentres at C23, C26 and C27. |
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| Keywords: | Antascomicin Immunosuppressant FKBP12 binding ligand Aldol reaction |
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