A short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed asymmetric α-aminooxylation |
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| Authors: | Shriram P Kotkar |
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| Institution: | Chemical Engineering and Process Development Division, National Chemical Laboratory, Pashan Road, Pune 411 008, India |
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| Abstract: | An efficient enantioselective synthesis of a new antiepileptic drug, levetiracetam is described, in high optical purity (>99.5% ee), using proline-catalyzed α-aminooxylation of n-butyraldehyde as the key step. |
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