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Synthesis of ‘difficult’ peptides free of aspartimide and related products, using peptoid methodology |
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| Authors: | Sotir Zahariev Corrado Guarnaccia Luca Quaroni Sándor Pongor |
| Institution: | a Protein Structure and Function Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy b Sincrotrone Trieste, Basovizza, I-34012 Trieste, Italy c University of Queensland, Brisbane 4072, Queensland, Australia |
| Abstract: | We developed an efficient, cost effective strategy for Fmoc-based solid phase synthesis of ‘difficult’ peptides and/or peptides containing Asp/Asn-Gly sequences, free of aspartimide and related products, using a peptoid methodology for the preparation of N-substituted glycines. |
| Keywords: | Aspartimide Backbone protection Caged peptides &lsquo difficult&rsquo peptides Peptoid |
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