Direct one-pot highly enantioselective assembly of polyketide and carbohydrate synthons |
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Authors: | Gui-Ling Zhao |
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Institution: | Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden |
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Abstract: | A short, direct, catalytic, enantioselective synthesis of polyketide segments and carbohydrates is presented. The novel, direct, one-pot, organocatalytic asymmetric tandem cross-aldol/Horner-Wittig-Emmons reactions assemble polyketide and carbohydrate derivatives in good yield with 93-98% ee. The one-pot catalytic asymmetric tandem reaction was applied to a highly enantioselective formal de novo synthesis of the rare carbohydrate, l-altrose. |
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