Application of carbenoid N-H insertion in the synthesis of the tricyclic 1,4-dihydropyrazines |
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| Authors: | Xuqing Zhang Zhihua Sui |
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| Affiliation: | Drug Discovery, Johnson & Johnson Pharmaceutical Research and Development, LLC, 665 Stockton Drive, Exton, PA 19341, USA |
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| Abstract: | The N-H insertion of the substituted anilines with 2-diazo-1,3-cyclohexanedione or 2-diazo-1,3-cyclopentanedione and subsequent cyclization enabled an efficient synthesis of a novel series of tricyclic 1,4-dihydropyrazines. |
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