Amide bond formation using an air-stable source of AlMe3 |
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| Authors: | Andrew Novak Matthew D Walker |
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| Institution: | a School of Chemistry, The University of Nottingham, Nottingham NG7 2RD, United Kingdom
b GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom |
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| Abstract: | Synthesis of amides from coupling esters with a range of primary amines can be conveniently achieved in moderate to excellent yields (69-99%) using an air-stable adduct of trimethylaluminium (AlMe3)2·DABCO (DABCO is 1,4-diazobicyclo2.2.2]octane), referred to as DABAL-Me3. Reactions can be run without requiring the exclusion of atmospheric oxygen or the drying of solvents. |
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