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An efficient one-pot synthesis of novel 4-aryl-1-methyloxindoles |
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| Authors: | Adri van den Hoogenband Jos H.M. Lange Wouter I. Iwema-Bakker Jack A.J. den Hartog Jord van Schaik Rolf W. Feenstra Jan Willem Terpstra |
| Affiliation: | Solvay Pharmaceuticals, Research Laboratories, C. J. van Houtenlaan 36, 1381 CP Weesp, The Netherlands |
| Abstract: | An unprecedented synthetic approach to novel 4-aryl-1-methyloxindoles is described. The method involves the intramolecular palladium-catalyzed amidation of N-methyl-2,6-dibromophenylacetamide followed by an in situ Suzuki cross-coupling reaction with a (hetero)arylboronic acid in a one-pot reaction. |
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