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An approach to the Paal-Knorr pyrroles synthesis catalyzed by Sc(OTf)3 under solvent-free conditions |
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| Authors: | Jiuxi Chen Zhiguo Zheng Xingxian Zhang |
| Institution: | a College of Chemistry and Materials Science, Wenzhou University, Wenzhou 325027, PR China b College of Pharmaceutical Sciences, Zhejiang University of Technology, Zhejiang Key Laboratory of Pharmaceutical Engineering, Hangzhou 310014, PR China c Zhejiang Hisoar Pharmaceutical Co., Ltd., Taizhou 318000, PR China |
| Abstract: | A facile synthesis of N-substituted pyrroles by the Paal-Knorr condensation has been accomplished using a simple procedure. Among different metal triflates screened, 1 mol % Sc(OTf)3 efficiently promoted the reaction to give excellent yield (89-98%) under mild reaction conditions. Additionally, Sc(OTf)3 could be recovered easily after the reactions and reused without evident loss in activity. |
| Keywords: | Scandium triflate Pyrrole Paal-Knorr Solvent-free conditions |
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