Enantioselective reduction of aliphatic ketones using NaBH4 and TarB-NO2, a chiral boronic ester |
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| Authors: | Jinsoo Kim |
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| Affiliation: | Department of Chemistry and Biochemistry, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA |
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| Abstract: | High enantioselectivities are obtained using a tartaric acid-derived boronic ester (TarB-NO2) in combination with NaBH4 for the asymmetric reduction of aliphatic ketones. The resulting alcohols are obtained in enantiomeric excesses ranging from 56% to 94%. |
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