A convenient synthesis of medium-sized lactams through RCM reaction of oxyoxazolidinones |
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| Authors: | Akio Kamimura Keiichi Tanaka Takahiro Hayashi Yoji Omata |
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| Institution: | Department of Applied Chemistry, Faculty of Engineering, Yamaguchi University, Ube 755-8611, Japan |
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| Abstract: | Oxyoxazolidinones, which are prepared from secondary O-acylmandelamides by treatment with TBSOTf, underwent the RCM reaction in the presence of Grubbs catalyst to give oxazoloazepines or oxazoloazecines, which were readily converted into N-unsubstituted seven-membered or eight-membered lactams by the reductive treatment. |
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