|
|||||
|
|
Copper-catalyzed N-arylation of oxindoles |
|
| Authors: | Dean P. Phillips Bao Nguyen Thomas L. Lau Matthew H. McNeill Jackline E. Dalgard Jyun-Hung Chen Richard J. Penuliar Todd A. Miller Lin Zhi |
| Affiliation: | Department of Medicinal Chemistry, Ligand Pharmaceuticals, 10275 Science Centre Drive, San Diego, CA 92121, USA |
| Abstract: | The coupling of aryl bromides or iodides with oxindoles using a copper iodide-N,N′-dimethylethylene diamine system is presented. The reaction proceeds efficiently and tolerates a variety of substitution patterns. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |