Total syntheses of the highly potent anti-cancer polyacetylenes, (S)-18-hydroxyminquartynoic acid, (S)-minquartynoic acid and (E)-15,16-dihydrominquartynoic acid |
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| Authors: | Gowravaram Sabitha Ch. Srinivas Reddy J.S. Yadav |
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| Affiliation: | Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | The total syntheses of three polyacetylenic natural products, (S)-18-hydroxyminquartynoic acid (1), (S)-minquartynoic acid (2) and (E)-15,16-dihydrominquartynoic acid (3), has been achieved. The Cadiot-Chodkiewicz cross-coupling reaction was used as the key step for the construction of tetrayne and triyne units. |
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| Keywords: | Natural products Polyacetylenes Cadiot-Chodkiewicz coupling Anti-cancer activity Anti-HIV activity |
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