Convenient synthesis of 1,2,3,4-tetrahydroquinolines via direct intramolecular reductive ring closure |
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| Authors: | Wuhong Chen Yuyuan Xie |
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| Institution: | State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China |
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| Abstract: | A simple and convenient procedure for the synthesis of 3-aryl-1,2,3,4-tetrahydroquinolines is reported. 3-Aryl-1,2,3,4-tetrahydroquinolines are directly obtained by reductive ring closure of 2-phenyl-3-(2-nitrophenyl)-propionitrile derivatives in moderate to high yields. |
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| Keywords: | Tetrahydroquinolines Synthesis Reductive ring closure |
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