Highly efficient chiral PNNP ligand for asymmetric transfer hydrogenation of aromatic ketones in water |
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| Authors: | Yan Xing |
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| Institution: | The State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, PR China |
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| Abstract: | Chiral PNNP ligand II and IrHCl2(COD)]2 were applied for the first time in the asymmetric transfer hydrogenation of aromatic ketones with HCOONa in water, giving the corresponding optical alcohols in high yield and excellent enantioselectivity (up to 99% ee). Particularly, the reduction of propiophenone proceeded smoothly at a substrate to catalyst molar ratio of 8000, without compromising the ee values obtained. |
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| Keywords: | Chiral ligand Aromatic ketone Asymmetric transfer hydrogenation |
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