A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides |
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| Authors: | Hemaka A Rajapakse Hong Zhu Mary Beth Young Bryan T Mott |
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| Institution: | Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA |
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| Abstract: | A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acids and acyl hydrazides is reported. Acid activation with CDI, followed by coupling with the desired acylhydrazide and dehydration in the same pot with Ph3P and CBr4 affords the corresponding 1,3,4-oxadiazoles in good yield. The scope of the acid and acylhydrazide components is presented. |
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| Keywords: | 1 3 4-Oxadiazole Synthesis One pot |
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