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Diastereoselective sulfur ylide promoted aldol/epoxidation |
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| Authors: | Jeffrey A. Hansen Colin R. Smith John C. Huffman |
| Affiliation: | a Department of Chemistry, DePauw University, Greencastle, IN 46135, USA b Department of Chemistry, Indiana University, Bloomington, IN 47405, USA |
| Abstract: | A mixture of cyclohexanone or 4-methylcyclohexanone and an aromatic aldehyde is treated with dimethylsulfoxonium methylide to effect a tandem aldol/epoxidation reaction. The resulting product contains three or four new stereocenters but only one of the possible four or eight diastereomers is formed. |
| Keywords: | Stereoselective Epoxidation Sulfur ylide |
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