Novel synthesis of sterically hindered N-substituted lactams from imides |
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Authors: | Mousumi Sannigrahi Patrick Pinto TM Chan Neng-Yang Shih F George Njoroge |
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Institution: | Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, United States |
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Abstract: | An efficient and practical synthesis of sterically hindered N-substituted lactams has been developed starting from simple starting materials. The stereochemistry of the synthetically useful N,N acetal intermediate has been established. |
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