Efficient Pd-catalyzed synthesis of 2-arylaminopyrimidines via microwave irradiation |
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| Authors: | Henry Q. Zhang Zhiren Xia Anil Vasudevan Stevan W. Djuric |
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| Affiliation: | Enabling Chemistry Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064, USA |
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| Abstract: | An efficient method for the synthesis of 2-arylaminopyrimidines via microwave assisted, Pd-mediated amination of 2-chloropyrimidine is reported. This method is superior to the classical heating process, particularly when one of starting materials is a heteroarylamine. |
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