An efficient asymmetric synthesis of (S)-2-cyclohexyl-2-phenylglycolic acid, the acid segment of oxybutynin |
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| Authors: | Siddharth Roy Nilmadhav Chattopadhyay |
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| Institution: | a NAA Unit, Central Forensic Science Laboratory, Bhabha Atomic Research Centre, Mumbai 400 085, India
b Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai 400 085, India |
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| Abstract: | An innovative and facile synthesis of the title compound has been developed starting from (R)-cyclohexylidene glyceraldehyde. The key step in the synthesis is a chiral template-driven Grignard addition with absolute diastereocontrol. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. |
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| Keywords: | Asymmetric synthesis (R)-cyclohexylidene glyceraldehyde Oxybutynin α-Hydroxy acid |
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