Highly regioselective Friedel-Crafts alkylation of indoles with α,β-unsaturated N-acylbenzotriazoles |
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Authors: | Xuefei Zou Cungui Cheng Lichun Kong Hui Mao |
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Institution: | Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua 321004, PR China |
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Abstract: | The Friedel-Crafts alkylation rather than acylation of indoles was realized with α,β-unsaturated acylbenzotriazoles catalyzed by samarium(III) iodide under reflux in anhydrous THF. The reaction was highly regioselective, and a series of new 3-substituted indole derivatives were obtained in moderate to good yields with the potential to be further transformed into various indole derivatives due to the presence of active acylbenzotriazole moiety. |
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Keywords: | Indoles Friedel-Crafts alkylation N-Cinnamoylbenzotriazoles Samarium(III) iodide |
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