A one-pot synthesis of 3-methyl-5-aryl-4H-pyrrolo[2,3-d]-isoxazoles |
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Authors: | E Rajanarendar G Mohan P Ramesh D Karunakar |
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Institution: | Department of Chemistry, Kakatiya University, Warangal 506 009, AP, India |
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Abstract: | Sharpless epoxidation of 4-amino-3-methyl-5-styrylisoxazoles 1 resulted in the formation of 3-methyl-5-aryl-4H-pyrrolo2,3-d]-isoxazoles 4 in a one-step reaction. The reaction initially involves epoxide formation, followed by ring-opening and cyclization. Finally dehydration leads to the title compounds. The pyrrolo2,3-d]-isoxazoles 4 were also synthesized via an alternative procedure. |
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Keywords: | Sharpless epoxidation Epoxide ring-opening Cyclization Dehydration One-pot synthesis |
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