Efficient enantioselective synthesis of orthogonally protected (R)-α-alkylserines compatible with the solid phase peptide synthesis |
| |
| Authors: | Stamatia Vassiliou Plato A Magriotis |
| |
| Institution: | a Department of Chemistry, Laboratory of Organic Chemistry, University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
b Department of Chemistry, New York University, 110 Washington Square East, New York, NY 10003, USA |
| |
| Abstract: | The Schöllkopf methodology for the asymmetric synthesis of α-amino acids, which was previously not applicable to the construction of quaternary α-amino acids, has been rendered not only suitable but also practical for this purpose and applied to a highly efficient enantioselective synthesis of orthogonally protected (R)-α-alkylserines suitable for the solid phase synthesis. |
| |
| Keywords: | α α-Disubstituted α-amino acids Quaternary α-amino acids (R)-α-Alkylserines Schö llkopf methodology tert-BuLi |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
