|
|||||
|
|
Sequenced cyclizations involving intramolecular capture of alkyl-oxyaminyl radicals. Synthesis of heterocyclic compounds |
|
| Authors: | Luz Marina Jaramillo-Gómez Alix Elena Loaiza Luz Amalia Ríos |
| Institution: | a Departamento de Química, Universidad del Valle, Apartado 25360, Cali, Colombia b Departamento de Química, Universidad del Cauca, Popayán, Colombia c Departamento de Química, Universidad de Caldas, Manizales, Colombia d Department of Chemistry, Ohio State University, Columbus, OH 43210, USA |
| Abstract: | A cascade radical cyclization process involving oxime ethers tethered to a brominated phenyl and an activated olefin moiety is described. The generated aryl radicals using tri-n-butyltin hydride react with the C N bond to yield neutral alkyl-oxyaminyl radicals, which were then simultaneously captured by the activated double bond to provide heterocyclic systems with a pyrrolidinic nucleus. |
| Keywords: | Trapping of alkyl-oxyaminyl radicals Cascade radical cyclizations Synthesis of N-heterocyclic compounds |
| 本文献已被 ScienceDirect 等数据库收录！ | |