New rhodium(II) catalyzed synthesis of 1,4-dicarbonyl compounds from α-diazo ketones using vinyl ethers as two-carbon synthons |
| |
Authors: | Sengodagounder Muthusamy Pandurangan Srinivasan |
| |
Affiliation: | School of Chemistry, Bharathidasan University, Tiruchirappalli 620 024, India |
| |
Abstract: | Rhodium(II) acetate catalyzed reactions of various α-diazo ketones, and vinyl ethers afforded γ-ketoaldehydes or 1,4-diketones in a facile manner. In this process, oxycyclopropanes are formed as intermediates, and are subsequently ring opened in the presence of the rhodium(II) acetate catalyst to furnish the corresponding 1,4-dicarbonyl compounds. The scope of this protocol has been demonstrated with the synthesis of a serotonin antagonist. |
| |
Keywords: | Diazocarbonyl compounds Diazo ketones Rhodium(II) acetate Vinyl ether |
本文献已被 ScienceDirect 等数据库收录! |
|