Phenylsilane as an active amidation reagent for the preparation of carboxamides and peptides |
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| Authors: | Zheming Ruan R. Michael Lawrence Christopher B. Cooper |
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| Affiliation: | Early Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 4000, Princeton, NJ 08543-4000, USA |
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| Abstract: | The use of phenylsilane as a mild coupling reagent for amidation reactions is reported. Applicability to both solution- and solid-phase chemistry has been demonstrated for a variety of amines and carboxylic acids. |
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