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Remarkable solvent effect in Barton-Zard pyrrole synthesis: application in an efficient one-step synthesis of pyrrole derivatives |
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| Authors: | Apurba Bhattacharya Sankara Cherukuri Nitinchandra Patel John A Grosso Venkatapuram A Palaniswamy |
| Institution: | a Department of Chemistry, Texas A&M University-Kingsville, Kingsville, TX 78363, United States b Bristol Myers Squibb Co., One Squibb Drive, PO Box 191, New Brunswick, NJ 08903-0191, United States |
| Abstract: | A unique solvent effect encountered in the Barton-Zard pyrrole synthesis was exploited to develop an efficient synthesis of pyrrole-2-esters. The chemistry was extended to a one-pot synthesis of pyrrole-2,4-dicarboxylates. |
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