Novel recoverable catalysts for asymmetric transfer hydrogenation |
| |
Authors: | Wei He Ru Jiang Xiao-Li Sun |
| |
Institution: | a Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, PR China b Department of Pharmacology, School of Pharmacy, Fourth Military Medical University, Xi’an 710032, PR China |
| |
Abstract: | 9-Amino(9-deoxy)epiquinine and 9-amino(9-deoxy)epicinchonine were applied in asymmetric transfer hydrogenation of aromatic ketones in both iridium and rhodium catalytic systems using i-propanol as the hydrogen source. Good to excellent conversions and enantioselectivities were observed with a variety of aromatic ketones. Moreover, the Ir complex and Rh complex of 9-amino(9-deoxy)cinchonine were recovered in high yields with dilute hydrochloric acid. The enantioselectivity of 1-phenylethanol was nearly maintained after six cycles. |
| |
Keywords: | Asymmetric transfer hydrogenation Cinchona alkaloids Aromatic ketones |
本文献已被 ScienceDirect 等数据库收录! |