Alkynylation of halo pyrimidines under Pd/C-copper catalysis: regioselective synthesis of 4- and 5-alkynylpyrimidines |
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| Authors: | Manojit Pal Venkateswara Rao Batchu Nalivela Kumara Swamy Srinivas Padakanti |
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| Affiliation: | Chemistry-Discovery Research, Dr. Reddy’s Laboratories Ltd, Bollaram Road, Miyapur, Hyderabad 500049, India |
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| Abstract: | 5-Bromo-4-chloro-6-methylpyrimidines underwent facile Pd/C-Cu catalyzed coupling reactions with a variety of terminal alkynes, which resulted in the corresponding 4-alkynyl-5-bromopyrimidines, regioselectively, with good yields. 4-Chloro-5-iodo-6-methylpyrimidine, however, yielded the corresponding 5-alkynyl-4-chloropyrimidines under the same reaction conditions. |
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| Keywords: | 4-Alkynyl-5-bromopyrimidine Palladium catalyst Terminal alkynes 5-Bromo-4-chloro-6-methylpyrimidine |
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