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Click chemistry to functionalise peptidomimetics |
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| Authors: | Daniela Arosio Matteo Bertoli Carlo Scolastico |
| Institution: | a Dipartimento di Chimica Organica e Industriale, Università Degli Studi di Milano, Via Venezian 21, I-20133 Milano, Italy b Centro Interdisciplinare Studi Bio-molecolari e Applicazioni Industriali (CISI), Via Fantoli 16/15, I-20138 Milano, Italy c C.N.R.—Istituto di Scienze e Tecnologie Molecolari (ISTM), Via Venezian 21, I-20133 Milano, Italy |
| Abstract: | Sharpless modified Huisgen’s 2+3] cycloaddition of azide and acetylenic derivatives was employed as an efficient and simple method to conjugate azabicycloalkane amino acids, mimics of a homoSer-Pro dipeptide, with biologically relevant partners. |
| Keywords: | Peptidomimetics Conjugates Click chemistry [2+3] Cycloaddition |
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