Synthesis of 1,5-disubstituted 4-haloimidazoles from α-aminonitriles |
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| Authors: | Vijaykumar G Pawar Koen Robeyns Frans Compernolle |
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| Institution: | a Molecular Design and Synthesis, K.U.-Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium
b Biochemistry, Molecular and Structural Biology, K.U.-Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium |
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| Abstract: | Synthesis of pharmaceutically important 1,5-disubstituted-4-haloimidazoles starting from α-aminonitriles is described. Some 1D and 2D NMR spectral features of these imidazoles are discussed. |
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| Keywords: | Imidazole α-Aminonitriles Triphosgene Vilsmeier reagents |
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