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A concise asymmetric route to the antibiotic macrolides patulolide A and pyrenophorin |
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| Authors: | K. Srinivasa Rao D. Srinivasa Reddy Javed Iqbal |
| Affiliation: | a Discovery Research, Dr. Reddy’s Laboratories Ltd., Miyapur, Hyderabad 500 049, AP, India b Chemistry Division, Institute of Science and Technology, JNT University, Kukatpally, Hyderabad 500 072, AP, India |
| Abstract: | In this letter, we describe an enantiospecific route to patulolide A and pyrenophorin through the synthesis of known protected seco acid precursors starting from commercially available (S)-ethyl lactate. |
| Keywords: | Patulolide A Pyrenophorin Macrolide |
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