A Baylis-Hillman approach to the synthesis of C1-C11 fragment of caribenolide I |
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| Authors: | Matar Seck Blandine Seon-Meniel |
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| Institution: | Laboratoire de Pharmacognosie associé au CNRS (BioCIS), Faculté de Pharmacie, Université Paris-Sud, rue Jean-Baptiste, Clément 92296 Châtenay Malabry, France |
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| Abstract: | Stereoselective synthesis of C1-C11 fragment of caribenolide I, a potent antitumour macrolide isolated from a marine dinoflagellate Amphidinium sp. is described. The key steps rely on asymmetric aldol reactions, to control the absolute configurations of C2, C3 and C10 stereogenic centres. |
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