Iron(III) triflate-catalyzed one-pot synthesis of acetal-type protected cyanohydrins from carbonyl compounds |
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| Authors: | Katsuyuki Iwanami |
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| Institution: | Faculty of Science, Ibaraki University, 2-1-1 Bunkyo, Mito 310-8512, Japan |
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| Abstract: | A variety of cyanohydrin THP ethers were readily prepared from carbonyl compounds with trimethylsilyl cyanide and tetrahydropyran-2-yl acetate under the influence of a catalytic amount of iron(III) triflate in a convenient one-pot procedure. This method was also effective to prepare O-protected cyanohydrins by various acetal-type protective groups. |
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| Keywords: | Iron(III) triflate Cyanation Cyanohydrin THP ether Acetal-type protective group Trimethylsilyl cyanide Carbonyl compounds |
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