Synthesis of novel heterocycles based on the structures of erythrina alkaloids |
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Authors: | AK Ganguly CH Wang D Biswas J Misiaszek A Micula |
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Institution: | Department of Chemistry and Chemical Biology, Stevens Institute of Technology, Hoboken, NJ 07030, USA |
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Abstract: | Erythrina alkaloids represented by structure (1) are known to possess potent CNS activities. In this article, we have completed the synthesis of modified heterocyclic core structures (4) of erythrina alkaloids incorporating groups, which are expected to be metabolically more stable. Finally, we have oxidatively rearranged (4) to yield novel heterocycles (5). |
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Keywords: | Radical reactions Heterocyclic chemistry |
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