First lipase catalysed resolution of epoxy enol esters |
| |
| Authors: | Sé bastien Gravil,Robert Chê nevert |
| |
| Affiliation: | a Laboratoire SEESIB UMR CNRS 6504, Université Blaise-Pascal, 63177 Aubière Cedex, France
b Département de chimie, Faculté des Sciences et de Génie, Université Laval, Québec, Canada G1K 7P4 |
| |
| Abstract: | We report the first enzyme-catalysed kinetic resolution of epoxy enol esters. The lipase-promoted hydrolysis of these compounds provided α-hydroxyketones or α-hydroxyaldehydes (arising from the spontaneous rearrangement of the epoxy enols) and the residual esters with moderate to good enantioselectivity (E up to 100). |
| |
| Keywords: | Enzyme catalysis Hydrolases Kinetic resolution Hydrolysis Epoxy enol esters |
| 本文献已被 ScienceDirect 等数据库收录！ |
