Stereoselective syntheses of (−)-tetrahydrolipstatin via Prins cyclisations |
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| Authors: | JS Yadav M Sridhar Reddy AR Prasad |
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| Institution: | Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
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| Abstract: | Stereoselective syntheses of (−)-tetrahydrolipstatin have been achieved via two divergent approaches through Prins cyclisations as the key steps. PCC mediated oxidative cleavage, Frater alkylation, Keck allylation, Sharpless asymmetric epoxidation and allylic cleavage were the other key steps employed. |
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| Keywords: | Anti-obesity Homoallylic alcohol Prins cyclisation and allylic cleavage |
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