Asymmetric cyanosilylation of ketones catalyzed by novel chiral N,N′-dioxide titanium complexes |
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| Authors: | Qinghan Li Jun Wang Xiaoming Feng |
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| Institution: | a Key Laboratory of Green Chemistry and Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China
b State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China |
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| Abstract: | A novel C2-symmetric chiral N,N′-dioxide titanium complex was described, which could efficiently catalyze the asymmetric cyanosilylation of ketones in high yields with up to 92% ee under mild conditions. In addition, the catalyst system was simple and the ligands could be easily prepared from commercially available chiral amino acid. |
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