|
|||||
|
|
Chromatography-free product separation in the Mitsunobu reaction |
|
| Authors: | Anthony J. Proctor John M. Clough Yingfa Li |
| Affiliation: | a School of Chemistry, Cardiff University, Main College, Park Place, Cardiff CF10 3AT, UK b Syngenta, Research Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK |
| Abstract: | Mitsunobu products can be isolated pure without column chromatography by first washing a solution of the crude reaction mixture in dichloromethane with 15% aqueous hydrogen peroxide followed by aqueous sodium sulfite. A final filtration through silica gel secures the pure Mitsunobu product. |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ | |