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Chromatography-free product separation in the Mitsunobu reaction |
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| Authors: | Anthony J Proctor John M Clough Yingfa Li |
| Institution: | a School of Chemistry, Cardiff University, Main College, Park Place, Cardiff CF10 3AT, UK b Syngenta, Research Chemistry, Jealott’s Hill International Research Centre, Bracknell, Berkshire RG42 6EY, UK |
| Abstract: | Mitsunobu products can be isolated pure without column chromatography by first washing a solution of the crude reaction mixture in dichloromethane with 15% aqueous hydrogen peroxide followed by aqueous sodium sulfite. A final filtration through silica gel secures the pure Mitsunobu product. |
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