A facile synthesis of α-amino-DOTA as a versatile molecular imaging probe |
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Authors: | Byunghee Yoo |
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Affiliation: | Department of Biomedical Engineering, Case Western Reserve University, 10900 Euclid Avenue Cleveland, OH 44106-7207, USA |
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Abstract: | An amino group has been introduced into one ligand of DOTA that can couple to peptidyl carboxylates by coupling α-brominated glycine to DO3A-tBu (1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid, tert-butylester)). α-Amino-DOTA was coupled to the carboxylate backbone terminus of a peptide to demonstrate the utility for derivatization. |
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Keywords: | DOTA T1 relaxivity MRI Molecular imaging |
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