Bioreductive synthesis of perfluorinated chiral alcohols |
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Authors: | Thomas C. Rosen,Ralf Feldmann,Pascal Dü nkelmann,Thomas Dauß mann |
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Affiliation: | Julich Chiral Solutions GmbH, Prof.-Rehm-Str. 1, D-52428 Jülich, Germany |
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Abstract: | Perfluorinated chiral alcohols are interesting building blocks for pharmaceuticals and agrochemicals. Different chiral (R)- and (S)-configured perfluorinated alcohols were produced by asymmetric reduction of the corresponding ketones. Commercially available alcohol dehydrogenases were used as catalyst in combination with different cofactor regenerating systems. High selectivities of >99% were observed in most cases. The results also demonstrate the influence of the CF3 group on reactivity and enantioselectivity of alcohol dehydrogenases. |
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