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A new rearranged and a new seco-ent-kaurane diterpenoids from Isodon parvifolius |
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| Authors: | Li-Mei Li Guo-You Li Wei-Lie Xiao Sheng-Hong Li Quan-Bin Han Li-Guang Lou |
| Institution: | a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China b Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China c Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai 200032, PR China d Graduate School of the Chinese Academy of Sciences, Beijing 100039, PR China |
| Abstract: | Parvifoline X (1), a new rearranged ent-kaurane diterpenoid, and parvifoline Y (2), a new 8,15-seco-ent-kaurane diterpenoid, were isolated from the leaves of Isodon parvifolius. Their structures were elucidated by spectroscopic methods including 2D NMR analysis, and supported by a biogenetic pathway. Parvifoline X (1), possessing a new 15(8→11)-abeo-7α,20-epoxy-ent-kaurane skeleton, was found from the genus Isodon for the first time. Compounds 1 and 2 were evaluated for their inhibitory activity against A549, HT-29, and K562 cell lines. Parvifoline Y (2) was the most cytotoxic against A549 cells with an IC50 value of 4.97 μM. |
| Keywords: | Isodon parvifolius Labiatae Parvifolines X and Y NMR data Cytotoxicity |
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