A solution to the component instability problem in the preparation of peptides containing C2-substituted cis-cyclobutane β-aminoacids: synthesis of a stable rhodopeptin analogue |
| |
Authors: | Olivier Roy |
| |
Institution: | Laboratoire SEESIB-CNRS, Département de Chimie, Université Blaise Pascal, Clermont-Ferrand II, 24 Avenue des Landais, 63177 Aubière cedex, France |
| |
Abstract: | Despite the inherent instability of C2-substituted cis-cyclobutane β-aminoacids, incorporation of such residues into peptides is shown to be possible through use of a 1-amino-2-(hydroxymethyl)cyclobutane derivative as a stable β-aminoacid surrogate. This synthetic strategy was validated by the synthesis of a rhodopeptin analogue. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|